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Species and strain differences in response to nitrobenzene exposure have been noted in inhalation studies using mice and rats. The reason for these differences and the toxicokinetics involved are not understood. Additional toxicokinetic studies in species other than rodents and attempts to estimate the sensitivity of humans relative to these test species would be valuable aids in interpreting the results of available toxicity studies and in understanding individual differences noted in response to nitrobenzene exposure.

In another study, both oand p-nitrophenols were found when O2 was present and phenol was also found when O2 was absent (Nojima and Kanno 1977). Photolysis by reaction with hydroxyl radicals or ozone was found to be insignificant in the troposphere (Atkinson et al. 1987). Based on laboratory studies, they projected half-lives of nitrobenzene of 180 days by reaction with hydroxyl radicals and more than 6 years by reaction with ozone in "clean" air. In typical, moderately "dirty" air, these values would decrease to 90 days and more than 2 years, respectively.

The incidence of "primaquine sensitivity" among Kurds, a Middle Eastern population, is 53%. Among American blacks, the incidence is 13%. Thus, individuals already exhibiting primaquine sensitivity would be expected to be more vulnerable to the additional hemolytic crisis that often follows 5 to 6 days after nitrobenzene exposure (Gosselin et al. 1984; Von Oettingen 1941). The presence of susceptible populations in the workplace is obviously of great concern since chronic and potentially high levels of exposure to nitrobenzene combined with a genetic predisposition toward methemoglobinemia can put certain individuals at very high risk (Linch 1974).

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Antiviral Colloidal Silver Composition (US Patent)

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