By Tobias Langenhan, Torsten Schöneberg

ISBN-10: 3319415212

ISBN-13: 9783319415215

ISBN-10: 3319415239

ISBN-13: 9783319415239

Latest examine on Adhesion GPCRs has unearthed striking revelations concerning the occasions that govern the sign transduction of those receptor molecules and the mobile and organ necessities for those indications. unforeseen and exceptional findings recommend that Adhesion GPCRs represent a bunch of receptors that feel mechanical stimuli and transcode them into metabotropic signs in the course of the motion of a unique activation paradigm. Interdisciplinary efforts transcending many parts of biomedical study together with pharmacology, body structure, genetics, telephone biology, structural biology, biochemistry and bioinformatics have been essential to unveil those basic homes. The clinical leaders within the box that carried this study attempt have teamed up the following to supply a accomplished review of our present realizing, how Adhesion GPCRs sign and the way those receptors form organ constitution and function.

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Get Adhesion G Protein-coupled Receptors: Molecular, PDF

Most recent study on Adhesion GPCRs has unearthed fantastic revelations in regards to the occasions that govern the sign transduction of those receptor molecules and the mobile and organ specifications for those indications. unforeseen and unheard of findings recommend that Adhesion GPCRs represent a bunch of receptors that feel mechanical stimuli and transcode them into metabotropic signs during the motion of a singular activation paradigm.

Extra info for Adhesion G Protein-coupled Receptors: Molecular, Physiological and Pharmacological Principles in Health and Disease

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Isolation and characteristics of the receptor from bovine brain membranes. Bioorg Khim 16(2):158–165 71. Geppert M, Khvotchev M, Krasnoperov V, Goda Y, Missler M, Hammer RE et al (1998) Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J Biol Chem 273(3):1705–1710 72. Hamann J, Kwakkenbos MJ, de Jong EC, Heus H, Olsen AS, van Lier RA (2003) Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence. Eur J Immunol 33 (5):1365–1371. 200323881 73.

BMC Evol Biol 8:129. 1186/1471-2148-8-129, PubMed PMID: 18452600, PubMed Central PMCID: PMC2396169 26. Nordstrom KJ, Fredriksson R, Schioth HB (2008) The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors. BMC Evol Biol 8:9. 1186/1471-2148-8-9, PubMed PMID: 18199322, PubMed Central PMCID: PMC2246102 27. Krishnan A, Almen MS, Fredriksson R, Schioth HB (2013) Remarkable similarities between the hemichordate (Saccoglossus kowalevskii) and vertebrate GPCR repertoire.

FASEB J 20 (14):2582–2584. 06-6500fje 74. 1, is closely related to CD97. Genomics 67 (2):188–200. 6238 75. Hamann J, Vogel B, van Schijndel GM, van Lier RA (1996) The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). J Exp Med 184(3):1185–1189, PubMed PMID: 9064337, PubMed Central PMCID: PMC2192782 76. Hamann J, Stortelers C, Kiss-Toth E, Vogel B, Eichler W, van Lier RA (1998) Characterization of the CD55 (DAF)-binding site on the seven-span transmembrane receptor CD97. Eur J Immunol 28(5):1701–1707.

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Adhesion G Protein-coupled Receptors: Molecular, Physiological and Pharmacological Principles in Health and Disease by Tobias Langenhan, Torsten Schöneberg


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