By J.P. Griffin

ISBN-10: 0080525830

ISBN-13: 9780080525839

ISBN-10: 0444824065

ISBN-13: 9780444824066

For two decades this publication, now in its fifth variation, has supplied info on hostile drug interactions that's unrivalled in insurance and scholarship.

Adverse drug reactions, lots of them ascribable to interactions with different medicinal drugs or with chemical compounds in meals or the surroundings, are notion to reason or complicate one in twenty of clinic admissions.

The ebook is comfortably divided into components: half 1 reviews on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic point, whereas half 2 contains drug interplay tables, divided and subdivided into different types of issues, and the medication utilized in the therapy of those disorders.

If security in medicinal drugs is to enhance, schooling of prescribers is extremely important. This publication, with its up to date and coordinated strategy, serves that objective good. the true danger, because the authors remind us, is the lack of know-how of practitioners, no longer the drug itself. the amount is for this reason an important addition to the cabinets of these chargeable for the prescription of gear, so that it will hinder a possible backlash whilst utilized in blend with different medications or chemical substances.

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Additional resources for A Manual of Adverse Drug Interactions, Fifth Edition (MANUAL OF ADVERSE DRUG INTERACTIONS)

Example text

The best approach for prevention of drug-drug incompatibility interactions is to use published information on the physical and chemical properties of medicinal agents which are to be used concomitantly and avoid their coming into direct contact. The pharmacist is the best health professional to advise on this and the best source of current information is the latest edition of Martindale, The Extra Pharmacopoeia (31st edition, 1996). ii. DRUG-CONTAINERIPACKAGING INTERACTIONS It is essential that pharmaceutical containers and packaging should not interact with a drug product and, conversely, that the drug product should not interact with the container or packaging.

4 Y Decrease due t o endogenous inhibitors. Not clinically significant. , 1983 u z 0 3m 'A ? I 23 5 a 5L? F %u =! V) Y, yes; N, no; MI, myocardial infarction; Transpl, transplant; IHD, ischaemic heart disease; COPD, chronic obstructive pulrriorlary disease: CVA, cerebro-vascular accident: AGP, a,-acid glycoprotein; K,, drug-protein association constant; miscel, miscellaneous; V,, apparent volume of distribution; Alc, alcoholic; NIDDM, non-insulin-dependent $ diabetes mellitus; IDDM, insulin-dependent diabetes mellitus.

Cimetidine-cephalothinlcephalexin Cimetidine had no effect on the renal clearance of the organic anion cephalothin, however, it reduced the renal clearance of the zwitterion cephalexin by 20%. It was concluded that cimetidines effect was specific for organic cations and that both anion and cation transport systems might be involved for those zwitterions that undergo tubular secretion. Cimetidine-metformin Cimetidine increased the area under the plasma metformin concentration-time curve by an average of 50%, this was associated with a 27% reduction in the renal clearance of metformin.

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A Manual of Adverse Drug Interactions, Fifth Edition (MANUAL OF ADVERSE DRUG INTERACTIONS) by J.P. Griffin


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